Cancer Cell International is calling for submissions to our Collection on Human Cancer Proteoforms.
As of the first week of May 2024, according to the data from the UniProt Knowledgebase, the human proteome has a record of 20,434 canonical as well as 22,080 non-canonical protein isoforms. Over the years, with the advancement of proteomic and sequencing technologies, more and more novel proteoforms are characterized and studied. In addition, the discovery of protein-encoding lncRNAs and circRNAs has also contributed to the ever-increasing number of human proteoforms, in which all these should be taken into consideration for their underlying biological/physiological significance and how aberrant proteoform expressions might contribute to various diseases including cancer.
In this collection, we welcome Original Research and Review articles focusing on human cancer proteoform research. The themes that we wish to include, but are not limited to, are the following:
- Novel functions of cancer-specific human proteoforms
- Global/systematic analysis of human cancer proteoforms
- Cancer-specific proteoforms as diagnostic biomarkers or therapeutic targets
- The development of novel strategies to modulate proteoforms function in cancer therapy.