BMC Gastroenterology welcomes submissions for our upcoming Collection on Disorders of gut-brain interaction. Ever since the famous pavlovian experiments we know that bidirectional communication between the gut and the brain occurs via neural, endocrine, and immune pathways, influencing not only digestive processes but also mood, cognition, and behavior.
Recent advances in neuroscience, microbiology, and gastroenterology have shed light on the role of the gut microbiota in modulating gut-brain communication. For instance, compositional and functional alterations in the gut microbiota have been implicated in a spectrum of GI disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and functional dyspepsia, as well as neuropsychiatric conditions such as anxiety, depression, and autism spectrum disorders. Furthermore, interdisciplinary research has led to the identification of specific microbial taxa associated with disease states and the development of microbiota-based interventions like fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection.
Elucidating the role of the microbiota in gut-brain axis dysfunction has opened new avenues for personalized medicine, where interventions can be tailored based on an individual's gut microbiota profile and neurobiological characteristics. Looking ahead, continued interdisciplinary collaboration holds promise for novel diagnostic tools, precision therapies, and preventive strategies targeting not only gastrointestinal and neuropsychiatric disorders but also systemic conditions influenced by gut-brain axis dysregulation.
We invite submissions that explore various aspects of disorders of gut-brain interaction, including but not limited to:
- Enteric nervous system function in gut-brain axis
- Neural, hormonal, and immunological mechanisms of gut-brain communication
- Efficacy of cognitive behavioral therapy in functional dyspepsia management
- Psychogastroenterology including gut directed hypnotherapy
- Microbiome influence on mood regulation
- Pain mechanisms and visceral hypersensitivity
- Stress response and gut health connection
- Hormonal signaling in gut-brain communication
- Novel biomarkers for diagnosing irritable bowel syndrome symptoms
- Gut microbiota composition and function in irritable bowel syndrome patients
- Epidemiology of disorders of gut-brain interaction
- Sex differences in disorders of gut-brain interaction
- Psychiatric comorbidity in disorders of gut-brain interaction
- Role of stress in functional dyspepsia pathophysiology
- Nutritional interventions for modulating gut-brain axis
This Collection supports and amplifies research related to SDG 3: Good Health & Well-Being.
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